Article
Observing in real time the evolution of artemisinin resistance in Plasmodium falciparum.
BMC medicine - 31 Mar 2015
Sibley Carol Hopkins
Abstract excerpt
Simple genetic changes that correlate with drug resistance are used routinely to identify resistant pathogens. These "molecular markers" have usually been defined long after the phenotype of resistance was noted. The molecular changes at the "end game" reflect a long and complex evolution of genetic changes, but once a solidly resistant set of changes assembles under drug selection, that genotype is likely to...
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