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Article

The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population.

Journal of the neurological sciences - 15 Aug 2016

Wei Yang, Yang Nannan, Xu Qian, Sun Qiying, Guo Jifeng, Li Kai, Liu Zhenhua, Yan Xinxiang, Zhu Xiongwei, Tang Beisha

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Genome-wide association studies have confirmed the association of single nucleotide polymorphisms (SNPs) located in the SNCA gene with the risk of PD. While hypomethylation of the SNCA intron-1 was observed in patients with sporadic PD, an association between SNCA SNPs and SNCA methylation levels has been identified. To investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27423554
DOI: 10.1016/j.jns.2016.05.037

Genes

SNCA

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