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Article

Infectious triggers and novel therapeutic opportunities in childhood B cell leukaemia.

Nature reviews. Immunology - 1 Sept 2021

Cobaleda Cesar, Vicente-Dueñas Carolina, Sanchez-Garcia Isidro

Abstract excerpt

B cell acute lymphoblastic leukaemia (B-ALL) is the most common form of childhood cancer. Although treatment has advanced remarkably in the past 50 years, it still fails in ~20% of patients. Recent studies revealed that more than 5% of healthy newborns carry preleukaemic clones that originate in utero, but only a small percentage of these carriers will progress to overt B-ALL. The drivers of progression are...

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Identifiers

PMID: 33558682
DOI: 10.1038/s41577-021-00505-2

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