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Article

Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect.

Nature communications - 5 Dec 2019

Cheng Aoxing, Zhang Peng, Wang Bo, Yang Dongdong, Duan Xiaotao, Jiang Yongliang, Xu Tian, Jiang Ya, Shi Jiahui, Ding Chengtao, Wu Gao, Sang Zhihong, Wu Qiang, Wang Hua, Wu Mian, Zhang Zhiyong, Pan Xin, Pan Yue-Yin, Gao Ping, Zhang Huafeng, Zhou Cong-Zhao, Guo Jing, Yang Zhenye

Abstract excerpt

Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether Aurora-A is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Aurora-A-mediated...

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Identifiers

PMID: 31804482
DOI: 10.1038/s41467-019-13485-8
PMCID: PMC6895051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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