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LHX2 Rewires the Metabolic and Epigenetic Landscape to Drive Tumor Progression in Prostate Cancer

3 Sept 2025

Abstract excerpt

Neuroendocrine prostate cancer (NEPC) evolves as an aggressive phenotype during prolonged androgen deprivation therapy, lacking effective clinical management. In this study, we elucidated a reciprocal metabolic-epigenetic mechanism involving a positive feedback loop between glycolysis and the transcription factor LHX2 that promotes prostate cancer progression. Mechanistically, enzalutamide-mediated inhibition of...

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PMID: 40899980
DOI: 10.1158/0008-5472.can-25-0587

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