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Warburg effect and lactylation in cancer: mechanisms for chemoresistance

22 Apr 2025

Abstract excerpt

In the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative "pain point" that requires immediate attention. Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic strategies. Importantly, existing studies have demonstrated that glucose metabolic reprogramming, commonly referred to as the Warburg effect or aerobic...

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PMID: 40264038
DOI: 10.1186/s10020-025-01205-6

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