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Article

Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia.

Current atherosclerosis reports - 29 Apr 2021

Escolà-Gil Joan Carles, Rotllan Noemí, Julve Josep, Blanco-Vaca Francisco

Abstract excerpt

PURPOSE OF REVIEW: We seek to establish whether high-density lipoprotein HDL metabolism and reverse cholesterol transport (RCT) impairment is an intrinsic feature of familial hypercholesterolemia (FH). RECENT FINDINGS: RCT from macrophages (m-RCT), a vascular cell type of major influence on atherosclerosis, is impaired in FH due to defective low-density lipoprotein receptor (LDLR) function via both the HDL- and...

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Share to Biological Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33914189
DOI: 10.1007/s11883-021-00928-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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