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Article

Network analysis reveals a causal role of mitochondrial gene activity in atherosclerotic lesion formation.

Atherosclerosis - 1 Dec 2017

Vilne Baiba, Skogsberg Josefin, Foroughi Asl Hassan, Talukdar Husain Ahammad, Kessler Thorsten, Björkegren Johan L M, Schunkert Heribert

Abstract excerpt

BACKGROUND AND AIMS: Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS: To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. the so called Reversa mouse model), we performed time-resolved analyses of mitochondrial...

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Source

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PMID: 29100060
DOI: 10.1016/j.atherosclerosis.2017.10.019

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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