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Article

Irradiation induces p53 loss of heterozygosity in breast cancer expressing mutant p53.

Communications biology - 1 Jan 2019

Ghaleb Amr, Yallowitz Alisha, Marchenko Natalia

Abstract excerpt

Mutations in one allele of the TP53 gene in cancer early stages are frequently followed by the loss of the remaining wild-type allele (LOH) during tumor progression. However, the clinical impact of TP53 mutations and p53LOH, especially in the context of genotoxic modalities, remains unclear. Using MMTV;ErbB2 model carrying a heterozygous R172H p53 mutation, we report a previously unidentified oncogenic activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31799437
DOI: 10.1038/s42003-019-0669-y
PMCID: PMC6881331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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