Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.

doi:10.1371/journal.pone.0118029

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Article

Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.

PloS one - 1 Jan 2015

Jiang Dadi, Dumur Catherine I, Massey H Davis, Ramakrishnan Viswanathan, Subler Mark A, Windle Jolene J

Abstract excerpt

p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of these mutants appear to have acquired novel functions beyond merely losing wild-type functions. To investigate these gain-of-function effects in vivo, we generated mice of three different genotypes: MMTV-Hras/p53(+/+), MMTV-Hras/p53(-/-), and MMTV-Hras/p53R172H/R172H. Salivary tumors from these mice were characterized...

Topics

Animals
Apoptosis
Doxorubicin
Gene Expression Regulation, Neoplastic
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mutation
Proto-Oncogene Proteins p21(ras)
Salivary Gland Neoplasms
Tumor Suppressor Protein p53

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Identifiers

PMID: 25695772
DOI: 10.1371/journal.pone.0118029
PMCID: PMC4335025

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