Article
Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish.
Oncogene - 22 Aug 2013
Guo L, Liew H P, Camus S, Goh A M, Chee L L, Lunny D P, Lane E B, Lane D P
Abstract excerpt
Mutant p53 proteins accumulate to high levels in human tumors and in preneoplastic lesions in the skin and fallopian tube. However examination of tissues from mice and fish that are homozygous for mutant p53 surprisingly showed that the protein was present only at low levels except in the tumors that arose in these animals. The mutant protein did accumulate, however, following treatment with ionizing radiation in...
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