Article

Basal p53 activity is differentially impacted by individual mutations, defining the immediate response to genotoxicity

2024-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Genotoxicity induces p53 to coordinate a cellular response, however basal p53 activity preserves genome integrity by maintaining low expression of its target genes that scan the DNA and quickly repair damage. Acquired p53 mutations disrupt this regulation and the cellular capacity to respond effectively to environmental insults. Three breast cancer cell lines with different p53 status: wild type...

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Literature Corpus work: 511084f5-9718-5a79-a96e-2fd26385ebe5
DOI: 10.1101/2024.09.05.611436

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