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Article

Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis.

Molecular cancer research : MCR - 1 Apr 2015

Yallowitz Alisha R, Li Dun, Lobko Anthony, Mott Daniel, Nemajerova Alice, Marchenko Natalia

Abstract excerpt

UNLABELLED: The EGFR family (ErbB2/Her2 and EGFR/ErbB1/Her1) often modulates the transcriptional program involved in promoting mammary tumorigenesis. In humans, the majority of ErbB2-positive sporadic breast cancers harbor p53 mutations, which correlate with poor prognosis. Also, the extremely high incidence of ErbB2-positive breast cancer in women with p53 germline mutations (Li-Fraumeni syndrome) suggests a key...

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Share to Carcinoma, Ductal, Breast
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Mammary Neoplasms, Experimental

Share to Neoplastic Stem Cells

Share to Receptor, ErbB-2

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 25573952
DOI: 10.1158/1541-7786.MCR-14-0360
PMCID: PMC4824060

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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