Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.

doi:10.1038/s42003-019-0634-9

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Article

Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.

Communications biology - 1 Jan 2019

Bonnemaijer Pieter W M, Leeuwen Elisabeth M van, Iglesias Adriana I, Gharahkhani Puya, Vitart Veronique, Khawaja Anthony P, Simcoe Mark, Höhn René, Cree Angela J, Igo Rob P, Gerhold-Ay Aslihan, Nickels Stefan, Wilson James F, Hayward Caroline, Boutin Thibaud S, Polašek Ozren, Aung Tin, Khor Chiea Chuen, Amin Najaf, Lotery Andrew J, Wiggs Janey L, Cheng Ching-Yu, Hysi Pirro G, Hammond Christopher J, Thiadens Alberta A H J, MacGregor Stuart, Klaver Caroline C W, Duijn Cornelia M van

Abstract excerpt

A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular...

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Identifiers

PMID: 31798171
DOI: 10.1038/s42003-019-0634-9
PMCID: PMC6881308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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