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Article

Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population.

Investigative ophthalmology & visual science - 28 Mar 2011

Fan Bao Jian, Wang Dan Yi, Pasquale Louis R, Haines Jonathan L, Wiggs Janey L

Abstract excerpt

PURPOSE: Genetically complex disorders, such as primary open angle glaucoma (POAG), may include highly heritable quantitative traits as part of the overall phenotype, and mapping genes influencing the related quantitative traits may effectively identify genetic risk factors predisposing to the complex disease. Recent studies have identified SNPs associated with optic nerve area and vertical cup-to-disc ratio...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21398277
DOI: 10.1167/iovs.10-6339
PMCID: PMC3101676

Genes

ATOH7
SIX1
SIX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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