Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association analysis of 95 549 individuals identifies novel loci and genes influencing optic disc morphology.

Human molecular genetics - 1 Nov 2019

Han Xikun, Qassim Ayub, An Jiyuan, Marshall Henry, Zhou Tiger, Ong Jue-Sheng, Hassall Mark M, Hysi Pirro G, Foster Paul J, Khaw Peng T, Mackey David A, Gharahkhani Puya, Khawaja Anthony P, Hewitt Alex W, Craig Jamie E, MacGregor Stuart

Abstract excerpt

Optic nerve head morphology is affected by several retinal diseases. We measured the vertical optic disc diameter (DD) of the UK Biobank (UKBB) cohort (N = 67 040) and performed the largest genome-wide association study (GWAS) of DD to date. We identified 81 loci (66 novel) for vertical DD. We then replicated the novel loci in International Glaucoma Genetic Consortium (IGGC, N = 22 504) and European Prospective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Databases, Factual

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genome-Wide Association Study

Share to Glaucoma

Share to Glaucoma and retinal disorders

Share to Optic Disk

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 31809533
DOI: 10.1093/hmg/ddz193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association analysis of 95 549 individuals identifies novel loci and genes influencing optic disc morphology.PMID 31809533Read ↗

Meta‐analysis of Genome‐Wide Association Studies Identifies Novel Loci Associated With Optic Disc MorphologySemantic proximity Read ↗

Large-scale machine-learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology.Semantic proximity Read ↗

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.Semantic proximity Read ↗

A genome-wide association study of optic disc parameters.Semantic proximity Read ↗

Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population.Semantic proximity Read ↗

Genome‐wide association studies in the hunt for genes causing primary open‐angle glaucoma: a reviewSemantic proximity Read ↗

Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.Semantic proximity Read ↗

GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphologySemantic proximity Read ↗

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.Semantic proximity Read ↗

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.Semantic proximity Read ↗

Common genetic variants associated with open-angle glaucoma.Semantic proximity Read ↗

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.