Article
A genome-wide association study of optic disc parameters.
PLoS genetics - 10 Jun 2010
Ramdas Wishal D, van Koolwijk Leonieke M E, Ikram M Kamran, Jansonius Nomdo M, de Jong Paulus T V M, Bergen Arthur A B, Isaacs Aaron, Amin Najaf, Aulchenko Yurii S, Wolfs Roger C W, Hofman Albert, Rivadeneira Fernando, Oostra Ben A, Uitterlinden Andre G, Hysi Pirro, Hammond Christopher J, Lemij Hans G, Vingerling Johannes R, Klaver Caroline C W, van Duijn Cornelia M
Abstract excerpt
The optic nerve head is involved in many ophthalmic disorders, including common diseases such as myopia and open-angle glaucoma. Two of the most important parameters are the size of the optic disc area and the vertical cup-disc ratio (VCDR). Both are highly heritable but genetically largely undetermined. We performed a meta-analysis of genome-wide association (GWA) data to identify genetic variants associated...
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