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Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.

Human genetics - 1 Apr 2023

Yao Xueming, Yang Hongxi, Han Han, Kou Xuejing, Jiang Yuhan, Luo Menghan, Zhou Yao, Wang Jianhua, Fan Xutong, Wang Xiaohong, Li Mulin Jun, Yan Hua

Abstract excerpt

Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness worldwide. Previous genome-wide association studies (GWASs) have revealed a variety of susceptible loci associated with age-related ocular disorders, yet the genetic pleiotropy and causal genes across these diseases remain poorly understood. By leveraging large-scale genetic and observational data from ocular disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36917350
DOI: 10.1007/s00439-023-02542-4

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