Article

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders

2022-07-17

Abstract excerpt

<h4>Purpose</h4> Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness worldwide. Previous genome-wide association studies (GWASs) have revealed a variety of susceptible loci associated with age-related ocular disorders, yet the genetic pleiotropy and causal genes across these diseases remain poorly understood. This study aims to identify genetic pleiotropic genes among AMD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc44cb0d-d469-5cc1-af8a-759f8d3a932e
DOI: 10.1101/2022.07.15.22277659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disordersDOI 10.1101/2022.07.15.22277659Read

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.Semantic proximity Read

Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.Semantic proximity Read

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.Semantic proximity Read

Advances in the genomics of common eye diseases.Semantic proximity Read

Gene and phenome-based analysis of the shared genetic architecture of eye diseases.Semantic proximity Read

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.Semantic proximity Read

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucomaSemantic proximity Read

Systematic dissection of pleiotropic loci and critical regulons in exhibitory neurons and microglia relevant to neuropsychiatric and ocular diseasesSemantic proximity Read

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.Semantic proximity Read

Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferationSemantic proximity Read

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.Semantic proximity Read

Cross-trait genomic and sequential analyses of multiple omics datasets identified shared genetic components for the gut-eye axis.Semantic proximity Read