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Article

Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys.

Nature communications - 4 Dec 2019

Luo Xin, He Yaoxi, Zhang Chao, He Xiechao, Yan Lanzhen, Li Min, Hu Ting, Hu Yan, Jiang Jin, Meng Xiaoyu, Ji Weizhi, Zhao Xudong, Zheng Ping, Xu Shuhua, Su Bing

Abstract excerpt

CRISPR-Cas9 is a widely-used genome editing tool, but its off-target effect and on-target complex mutations remain a concern, especially in view of future clinical applications. Non-human primates (NHPs) share close genetic and physiological similarities with humans, making them an ideal preclinical model for developing Cas9-based therapies. However, to our knowledge no comprehensive in vivo off-target and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31797925
DOI: 10.1038/s41467-019-13481-y
PMCID: PMC6892871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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