Article
Multiplex precise base editing in cynomolgus monkeys.
Nature communications - 11 May 2020
Zhang Wenhui, Aida Tomomi, Del Rosario Ricardo C H, Wilde Jonathan J, Ding Chenhui, Zhang Xiaohui, Baloch Zulqurain, Huang Yan, Tang Yu, Li Duanduan, Lu Hongyu, Zhou Yang, Jiang Minqing, Xu Dongdong, Fang Zhihao, Zheng Zhanhong, Huang Qunshan, Feng Guoping, Yang Shihua
Abstract excerpt
Common polygenic diseases result from compounded risk contributed by multiple genetic variants, meaning that simultaneous correction or introduction of single nucleotide variants is required for disease modeling and gene therapy. Here, we show precise, efficient, and simultaneous multiplex base editing of up to three target sites across 11 genes/loci in cynomolgus monkey embryos using CRISPR-based cytidine- and...
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