Article

Trio deep-sequencing does not reveal unexpected mutations in Cas9-edited monkeys

2018-06-05

Abstract excerpt

CRISPR-Cas9 is a widely-used genome editing tool, but its off-target effect remains a concern, especially in view of future clinical applications. Non-human primates (NHPs) share close genetic and physiological similarities with humans, making them an ideal preclinical model for developing Cas9-based therapies. However, no comprehensive in vivo off-target assessment has been conducted in NHPs. Here we performed w...

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Literature Corpus work: 7bcdfe38-dd75-53c3-b677-4a1813bf4f39
DOI: 10.1101/339143

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