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Article

Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep.

BMC genomics - 25 May 2018

Wang Xiaolong, Liu Jing, Niu Yiyuan, Li Yan, Zhou Shiwei, Li Chao, Ma Baohua, Kou Qifang, Petersen Bjoern, Sonstegard Tad, Huang Xingxu, Jiang Yu, Chen Yulin

Abstract excerpt

BACKGROUND: The simplicity of the CRISPR/Cas9 system has enabled its widespread applications in generating animal models, functional genomic screening and in treating genetic and infectious diseases. However, unintended mutations produced by off-target CRISPR/Cas9 nuclease activity may lead to negative consequences. Especially, a very recent study found that gene editing can introduce hundreds of unintended...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29801435
DOI: 10.1186/s12864-018-4712-z
PMCID: PMC5970491

Genes

MSTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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