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Article

Whole genome sequencing predicts novel human disease models in rhesus macaques.

Genomics - 1 Jul 2017

Bimber Benjamin N, Ramakrishnan Ranjani, Cervera-Juanes Rita, Madhira Ravi, Peterson Samuel M, Norgren Robert B, Ferguson Betsy

Abstract excerpt

Rhesus macaques are an important pre-clinical model of human disease. To advance our understanding of genomic variation that may influence disease, we surveyed genome-wide variation in 21 rhesus macaques. We employed best-practice variant calling, validated with Mendelian inheritance. Next, we used alignment data from our cohort to detect genomic regions likely to produce inaccurate genotypes, potentially due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28438488
DOI: 10.1016/j.ygeno.2017.04.001
PMCID: PMC5513488

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