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Article

No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy.

The Journal of biological chemistry - 27 Jul 2018

Wang Shuang, Ren Shuaiwei, Bai Raoxian, Xiao Puhao, Zhou Qin, Zhou Yin, Zhou Zhigang, Niu Yuyu, Ji Weizhi, Chen Yongchang

Abstract excerpt

CRISPR/Cas9 is now widely used in biomedical research and has great potential for clinical applications. However, the safety and efficacy of this gene-editing technique are significant issues. Recent reports on mouse models and human cells have raised concerns that off-target mutations could hamper applying the CRISPR technology in patients. The high similarities of nonhuman primates to humans in genome content...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29941452
DOI: 10.1074/jbc.AC118.004404
PMCID: PMC6066302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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