PhySigs: Phylogenetic Inference of Mutational Signature Dynamics.

Abstract excerpt

Distinct mutational processes shape the genomes of the clones comprising a tumor. These processes result in distinct mutational patterns, summarized by a small number of mutational signatures. Current analyses of clone-specific exposures to mutational signatures do not fully incorporate a tumor's evolutionary context, either inferring identical exposures for all tumor clones, or inferring exposures for each clone...

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