Article
Assessing the contribution of tumor mutational phenotypes to cancer progression risk.
PLoS computational biology - 1 Mar 2021
Tao Yifeng, Rajaraman Ashok, Cui Xiaoyue, Cui Ziyi, Chen Haoran, Zhao Yuanqi, Eaton Jesse, Kim Hannah, Ma Jian, Schwartz Russell
Abstract excerpt
Cancer occurs via an accumulation of somatic genomic alterations in a process of clonal evolution. There has been intensive study of potential causal mutations driving cancer development and progression. However, much recent evidence suggests that tumor evolution is normally driven by a variety of mechanisms of somatic hypermutability, which act in different combinations or degrees in different cancers. These...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.