Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Outcome of Leiomyosarcomas With Somatic Alteration in Homologous Recombination Pathway Genes

1 Nov 2020

Abstract excerpt

PURPOSE To detect alterations in DNA damage repair (DDR) genes, measure homologous recombination deficiency (HRD), and correlate these findings with clinical outcome in patients with leiomyosarcoma (LMS). PATIENTS AND METHODS Patients with LMS treated at Memorial Sloan Kettering (MSK) Cancer Center who consented to prospective targeted next-generation sequencing with MSK-IMPACT were screened for oncogenic somatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33283135
DOI: 10.1200/po.20.00122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Outcome of Leiomyosarcomas With Somatic Alteration in Homologous Recombination Pathway GenesPMID 33283135Read ↗

Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilitiesSemantic proximity Read ↗

Integrative genomic and transcriptomic analysis of leiomyosarcoma.Semantic proximity Read ↗

Role of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective AnalysisSemantic proximity Read ↗

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.Semantic proximity Read ↗

Genomic Characteristics of Leiomyosarcoma: An AACR Project GENIE Study.Semantic proximity Read ↗

Targeting homologous recombination deficiency in uterine leiomyosarcomaSemantic proximity Read ↗

Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.Semantic proximity Read ↗

Next generation sequencing reveals a high prevalence of pathogenic mutations in homologous recombination DNA damage repair genes among patients with uterine sarcoma.Semantic proximity Read ↗

Integrated Genomic and Transcriptomic Analysis Revealed Mutation Patterns of De-differentiated Liposarcoma and LeiomyosarcomaSemantic proximity Read ↗

Integrated mutational landscape analysis of uterine leiomyosarcomas.Semantic proximity Read ↗

The Future of Targeted Therapy for LeiomyosarcomaSemantic proximity Read ↗

Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.