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Clinicogenomic characteristics and synthetic lethal implications of germline homologous recombination-deficient hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Aug 2023

An Jihyun, Oh Ji-Hye, Oh Bora, Oh Yoo-Jin, Ju Jin-Sung, Kim Wonkyung, Kang Hyo Jung, Sung Chang Ohk, Shim Ju Hyun

Abstract excerpt

BACKGROUNDS AND AIMS: We performed an in-depth examination of pathogenic germline variants (PGVs) and somatic variants in DNA damage response (DDR) genes in hepatocellular carcinoma (HCC) to explore their clinical and genomic impacts. APPROACH AND RESULTS: We used a merged whole-exome or RNA sequencing data set derived from in-house ( n = 230) and The Cancer Genome Atlas ( n = 362) databases of multiethnic HCC...

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Identifiers

PMID: 36177702
DOI: 10.1002/hep.32812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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