Article
Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes.
Carcinogenesis - 1 Aug 2016
Mimaki Sachiyo, Totsuka Yukari, Suzuki Yutaka, Nakai Chikako, Goto Masanori, Kojima Motohiro, Arakawa Hirofumi, Takemura Shigekazu, Tanaka Shogo, Marubashi Shigeru, Kinoshita Masahiko, Matsuda Tomonari, Shibata Tatsuhiro, Nakagama Hitoshi, Ochiai Atsushi, Kubo Shoji, Nakamori Shoji, Esumi Hiroyasu, Tsuchihara Katsuya
Abstract excerpt
Cholangiocarcinoma is a relatively rare cancer, but its incidence is increasing worldwide. Although several risk factors have been suggested, the etiology and pathogenesis of the majority of cholangiocarcinomas remain unclear. Recently, a high incidence of early-onset cholangiocarcinoma was reported among the workers of a printing company in Osaka, Japan. These workers underwent high exposure to organic solvents,...
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