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Article

Loss of TOP3B leads to increased R-loop formation and genome instability

1 Dec 2019

Abstract excerpt

Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease. A homozygous deletion for the TOP3B gene was identified in a patient with bilateral renal cancer. Analyses in both patient and modelled human cells show the disruption of TOP3B causes genome instability...

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Identifiers

PMID: 31795919
DOI: 10.1098/rsob.190222

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