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Article

Molecular Evolution of DNA Topoisomerase III Beta (TOP3B) in Metazoa.

Journal of molecular evolution - 1 Jul 2021

Moreira Filipa, Arenas Miguel, Videira Arnaldo, Pereira Filipe

Abstract excerpt

DNA topoisomerase III beta (TOP3B) is unique by operating on both DNA and RNA substrates to regulate gene expression and genomic stability. Mutations in human TOP3B are linked to neurodevelopmental and cognitive disorders, highlighting its relevance for human health. Despite the emerging importance of TOP3B, its precise cellular functions and evolutionary history remain poorly understood. Here, we show that TOP3B...

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PMID: 33999213
DOI: 10.1007/s00239-021-10011-7

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