Article
Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.
Molecular and cellular biology - 1 Aug 2006
Seki Masayuki, Nakagawa Takayuki, Seki Takahiko, Kato Genta, Tada Shusuke, Takahashi Yuriko, Yoshimura Akari, Kobayashi Takayuki, Aoki Ayako, Otsuki Makoto, Habermann Felix A, Tanabe Hideyuki, Ishii Yutaka, Enomoto Takemi
Abstract excerpt
Bloom's syndrome (BS) is an autosomal disorder characterized by predisposition to a wide variety of cancers. The gene product whose mutation leads to BS is the RecQ family helicase BLM, which forms a complex with DNA topoisomerase IIIalpha (Top3alpha). However, the physiological relevance of the interaction between BLM and Top3alpha within the cell remains unclear. We show here that Top3alpha depletion causes...
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