Article
The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.
The Journal of biological chemistry - 14 Jul 2017
Nakatsu Yusuke, Mori Keiichi, Matsunaga Yasuka, Yamamotoya Takeshi, Ueda Koji, Inoue Yuki, Mitsuzaki-Miyoshi Keiko, Sakoda Hideyuki, Fujishiro Midori, Yamaguchi Suguru, Kushiyama Akifumi, Ono Hiraku, Ishihara Hisamitsu, Asano Tomoichiro
Abstract excerpt
The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion. This report is the first to show that Pin1 expression in pancreatic β cells is markedly elevated by high-fat diet feeding and in ob/ob mice. To elucidate the role of Pin1 in pancreatic β cells, we generated β-cell-specific Pin1 KO (βPin1 KO) mice. These mutant mice showed...
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