Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.

doi:10.1074/jbc.M113.485730

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Article

Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.

The Journal of biological chemistry - 12 Jul 2013

Zhang Jun, Nakatsu Yusuke, Shinjo Takanori, Guo Ying, Sakoda Hideyuki, Yamamotoya Takeshi, Otani Yuichiro, Okubo Hirofumi, Kushiyama Akifumi, Fujishiro Midori, Fukushima Toshiaki, Tsuchiya Yoshihiro, Kamata Hideaki, Iwashita Misaki, Nishimura Fusanori, Katagiri Hideki, Takahashi Shin-ichiro, Kurihara Hiroki, Uchida Takafumi, Asano Tomoichiro

Abstract excerpt

Pin1 and Par14 are parvulin-type peptidyl-prolyl cis/trans isomerases. Although numerous proteins have been identified as Pin1 substrates, the target proteins of Par14 remain largely unknown. Par14 expression levels are increased in the livers and embryonic fibroblasts of Pin1 KO mice, suggesting a compensatory relationship between the functions of Pin1 and Par14. In this study, the association of Par14 with...

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PMID: 23720771
DOI: 10.1074/jbc.M113.485730
PMCID: PMC3711332

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