Article
Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice.
Diabetes - 1 Nov 2021
Gao Huanqing, Zhong Yiming, Ding Zhen, Lin Sixiong, Hou Xiaoting, Tang Wanze, Zhou Xiaoqian, Zou Xuenong, Shao Jie, Yang Fan, Bai Xiaochun, Liu Chuanju, Cao Huiling, Xiao Guozhi
Abstract excerpt
The mammalian focal adhesion proteins Pinch1/2 activate integrins and promote cell-extracellular matrix adhesion and migration; however, their roles in adipose tissue and metabolism are unclear. Here we find that high-fat diet (HFD) feeding dramatically increases expression of Pinch1/2 proteins in white adipose tissue (WAT) in mice. Furthermore, expression of Pinch1 is largely upregulated in WAT in...
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