Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organotypic brain slice cultures to model neurodegenerative proteinopathies

1 Dec 2019

Abstract excerpt

Organotypic slice cultures of brain or spinal cord have been a longstanding tool in neuroscience research but their utility for understanding Alzheimer's disease (AD) and other neurodegenerative proteinopathies has only recently begun to be evaluated. Organotypic brain slice cultures (BSCs) represent a physiologically relevant three-dimensional model of the brain. BSCs support all the central nervous system (CNS)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurological diseases and metabolism
Share to Prion Diseases and Protein Misfolding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31791377
DOI: 10.1186/s13024-019-0346-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organotypic brain slice cultures to model neurodegenerative proteinopathiesPMID 31791377Read ↗

Preparation of organotypic brain slice cultures for the study of Alzheimer’s diseaseSemantic proximity Read ↗

Modeling neurological disorders using brain organoids.Semantic proximity Read ↗

Pushing the boundaries of brain organoids to study Alzheimer's disease.Semantic proximity Read ↗

Modelling neurodegenerative disease using brain organoids.Semantic proximity Read ↗

Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies.Semantic proximity Read ↗

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.Semantic proximity Read ↗

Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.Semantic proximity Read ↗

Studying neurodegenerative diseases in culture modelsSemantic proximity Read ↗

Modeling Alzheimer’s Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational ModelingSemantic proximity Read ↗

Cerebral organoids for modeling of HSV-1-induced-multiscale neuropathology associated with Alzheimer’s disease and phenotypic rescueSemantic proximity Read ↗

Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug DiscoverySemantic proximity Read ↗

Brain Organoids in Parkinson’s Disease Drug Development: Human-Specific Models for Translational DiscoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.