Article
A mathematical framework to determine the temporal sequence of somatic genetic events in cancer.
Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 2010
Attolini Camille Stephan-Otto, Cheng Yu-Kang, Beroukhim Rameen, Getz Gad, Abdel-Wahab Omar, Levine Ross L, Mellinghoff Ingo K, Michor Franziska
Abstract excerpt
Human cancer is caused by the accumulation of genetic alterations in cells. Of special importance are changes that occur early during malignant transformation because they may result in oncogene addiction and represent promising targets for therapeutic intervention. Here we describe a computational approach, called Retracing the Evolutionary Steps in Cancer (RESIC), to deduce the temporal sequence of genetic...
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