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Article

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.

Leukemia - 1 Jul 2012

Reckzeh K, Bereshchenko O, Mead A, Rehn M, Kharazi S, Jacobsen S-E, Nerlov C, Cammenga J

Abstract excerpt

Biallelic CEBPA mutations and FMS-like tyrosine kinase receptor 3 (FLT3) length mutations are frequently identified in human acute myeloid leukemia (AML) with normal cytogenetics. However, the molecular and cellular mechanisms of oncogene cooperation remain unclear because of a lack of disease models. We have generated an AML mouse model using knockin mouse strains to study cooperation of an internal tandem...

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Share to CCAAT-Enhancer-Binding Proteins
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 22318449
DOI: 10.1038/leu.2012.37

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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