Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia

6 Apr 2006

Abstract excerpt

In leukemogenesis, several genetic changes conferring a proliferative and/or survival advantage to hematopoietic progenitor cells in addition to a block in differentiation are required. Here, we demonstrate that overexpression of the wild-type (wt) Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions (NUP98-HOXA10 and NUP98-HOXD13) to induce aggressive acute myeloid leukemia (AML). We used a mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Genomics and Chromatin Dynamics
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16861351
DOI: 10.1182/blood-2005-12-007005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemiaPMID 16861351Read ↗

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1Semantic proximity Read ↗

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.Semantic proximity Read ↗

Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction.Semantic proximity Read ↗

Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.Semantic proximity Read ↗

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse modelSemantic proximity Read ↗

Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion GenesSemantic proximity Read ↗

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.Semantic proximity Read ↗

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.Semantic proximity Read ↗

Oncogenic interaction between BCR-ABL andNUP98-HOXA9 demonstrated by the use of an in vitro purging culture systemSemantic proximity Read ↗

Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation.Semantic proximity Read ↗

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsSemantic proximity Read ↗

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.