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Article

Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis.

Leukemia - 1 Jul 2012

Quintana-Bustamante O, Lan-Lan Smith S, Griessinger E, Reyal Y, Vargaftig J, Lister T A, Fitzgibbon J, Bonnet D

Abstract excerpt

CCAAT/enhancer-binding protein-α (C/EBPα/CEBPA) is mutated in approximately 8% of acute myeloid leukemia (AML) in both familial and sporadic AML and, with FLT3 and NPM1, has received most attention as a predictive marker of outcome in patients with normal karyotype disease. Mutations clustering to either the N- or C-terminal (N- and C-ter) portions of the protein have different consequences on the protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Leukemic

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Source

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Identifiers

PMID: 22371011
DOI: 10.1038/leu.2012.38
PMCID: PMC3378638

Genes

FLT3
NPM1

Provenance

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