Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GAB2 couples genetic drivers and signaling networks in acute myeloid leukemia.

The Journal of clinical investigation - 3 Nov 2025

Luvisotto Amanda, Wang Lu

Abstract excerpt

In acute myeloid leukemia (AML), leukemogenesis is typically driven by the sequential acquisition of distinct classes of mutations that collaborate to transform normal hematopoietic stem and progenitor cells. The founding and cooperating mutations in AML are often in signaling genes and form functional partnerships with each other, each addressing complementary aspects of malignant transformation. In this issue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Leukemia, Myeloid, Acute

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 41178718
DOI: 10.1172/JCI198684
PMCID: PMC12578398

Genes

GAB2
DNMT3A
GRB2
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GAB2 couples genetic drivers and signaling networks in acute myeloid leukemia.PMID 41178718Read ↗

Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression.Semantic proximity Read ↗

Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.Semantic proximity Read ↗

Molecular pathogenesis of AML: translating insights to the clinic.Semantic proximity Read ↗

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.Semantic proximity Read ↗

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Semantic proximity Read ↗

Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation.Semantic proximity Read ↗

AMKL chimeric transcription factors are potent inducers of leukemia.Semantic proximity Read ↗

Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation.Semantic proximity Read ↗

Targeting AML at the intersection of epigenetics and signaling.Semantic proximity Read ↗

Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.Semantic proximity Read ↗

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.Semantic proximity Read ↗

Molecular genetics of human leukemias: new insights into therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.