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Article

Role of mtDNA disturbances in the pathogenesis of Alzheimer's and Parkinson's disease.

DNA repair - 1 Jan 2000

Antonyová Veronika, Kejík Zdeněk, Brogyányi Tereza, Kaplánek Robert, Pajková Martina, Talianová Veronika, Hromádka Róbert, Masařík Michal, Sýkora David, Mikšátková Lucie, Martásek Pavel, Jakubek Milan

Abstract excerpt

Neurodegenerative diseases (e.g. Alzheimer's and Parkinson's disease) are becoming increasingly problematic to healthcare systems. Therefore, their underlying mechanisms are trending topics of study in medicinal research. Numerous studies have evidenced a strong association between mitochondrial DNA disturbances (e.g. oxidative damage, mutations, and methylation shifts) and the initiation and progression of...

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PMID: 32502755
DOI: 10.1016/j.dnarep.2020.102871

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