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Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature.

Pathology, research and practice - 1 Feb 2020

Luangxay Thitsamay, Osako Tomo, Yonekura Rika, Sugiura Yoshiya, Kikuchi Mari, Gomi Naoya, Ueno Takayuki, Ohno Shinji, Machinami Rikuo, Takeuchi Kengo, Akiyama Futoshi

Abstract excerpt

Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. We report a unique case of breast GCT-ST coincident with ductal carcinoma in situ (DCIS), diagnosed with histological, immunohistochemical, and H3F3A (Histone H3.3) mutation analyses. A 59-year-old woman preoperatively diagnosed with DCIS underwent total mastectomy for a cystic mass. Histology revealed a tumor composed of...

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Identifiers

PMID: 31784095
DOI: 10.1016/j.prp.2019.152750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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