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Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2020

Qu Lala, Zhang Xiuli, Wang Jixia, Zhou Han, Hou Tao, Wei Lai, Xu Fangfang, Liang Xinmiao

Abstract excerpt

Endothelin receptors, consisting of two subtypes, ETA and ETB, are expressed in various tissues and widely regulate cardiovascular systems. The two receptors show distinct biological characteristics and are involved in different downstream pathways. Hence, to evaluate the ETA and ETB receptors on the same platform is helpful to display their pharmacological features. In this study, we developed a label-free...

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PMID: 31781785
DOI: 10.1007/s00210-019-01756-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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