Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes.

Nucleic acids research - 24 Jan 2020

Bachar Amit, Itzhaki Elad, Gleizer Shmuel, Shamshoom Melina, Milo Ron, Antonovsky Niv

Abstract excerpt

Identifying the molecular mechanisms that give rise to genetic variation is essential for the understanding of evolutionary processes. Previously, we have used adaptive laboratory evolution to enable biomass synthesis from CO2 in Escherichia coli. Genetic analysis of adapted clones from two independently evolving populations revealed distinct enrichment for insertion and deletion mutational events. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomass
Share to Carbon Dioxide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

Share to Drug Resistance, Bacterial

Share to Escherichia coli Proteins

Share to Gene Duplication

Share to MutS DNA Mismatch-Binding Protein

Share to Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 31777935
DOI: 10.1093/nar/gkz1100
PMCID: PMC6954433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes.PMID 31777935Read ↗

Mutational Signatures in Wild Type Escherichia coli Strains Reveal Predominance of DNA Polymerase Errors.Semantic proximity Read ↗

Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress.Semantic proximity Read ↗

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Semantic proximity Read ↗

A case of adaptation through a mutation in a tandem duplication during experimental evolution in Escherichia coli.Semantic proximity Read ↗

Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.Semantic proximity Read ↗

Metagenomic DNA fragments that affect Escherichia coli mutational pathways.Semantic proximity Read ↗

Temperature responses of mutation rate and mutational spectrum in an Escherichia coli strain and the correlation with metabolic rate.Semantic proximity Read ↗

Mutation bias influences the emergence and effects of antibiotic resistanceSemantic proximity Read ↗

The essential role of hypermutation in rapid adaptation to antibiotic stressSemantic proximity Read ↗

Antibiotic treatment enhances the genome-wide mutation rate of target cells.Semantic proximity Read ↗

The origin of the logic of adaptive mutations: standing by to grow again.Semantic proximity Read ↗

Genomic analysis reveals distinct concentration-dependent evolutionary trajectories for antibiotic resistance in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.