Article
Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress.
Research in microbiology - 1 Jun 2004
Hersh Megan N, Ponder Rebecca G, Hastings P J, Rosenberg Susan M
Abstract excerpt
The neo-Darwinists suggested that evolution is constant and gradual, and thus that genetic changes that drive evolution should be too. However, more recent understanding of phenomena called adaptive mutation in microbes indicates that mutation rates can be elevated in response to stress, producing beneficial and other mutations. We review evidence that, in Escherichia coli, two separate mechanisms of...
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