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Article

Mechanisms of Resistance Associated with the Inhibition of the Dehydration Step of Type II Fatty Acid Synthase in Mycobacterium tuberculosis.

ACS infectious diseases - 14 Feb 2020

Grzegorzewicz Anna E, Gee Clifford, Das Sourav, Liu Jiuyu, Belardinelli Juan Manuel, Jones Victoria, McNeil Michael R, Lee Richard E, Jackson Mary

Abstract excerpt

Isoxyl (ISO) and thiacetazone (TAC) are two antitubercular prodrugs that abolish mycolic acid biosynthesis and kill Mycobacterium tuberculosis (Mtb) through the inhibition of the essential type II fatty acid synthase (FAS-II) dehydratase HadAB. While mutations preventing ISO and TAC either from being converted to their active form or from covalently modifying their target are the most frequent spontaneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31775512
DOI: 10.1021/acsinfecdis.9b00162
PMCID: PMC8078599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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