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Article

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues.

PloS one - 1 Jan 2013

Coxon Geoffrey D, Craig Derek, Corrales Rosa Milagros, Vialla Emilie, Gannoun-Zaki Laila, Kremer Laurent

Abstract excerpt

Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis. Thiacetazone (TAC) is an anti-tubercular drug that was formerly used in conjunction with isoniazid, but removed from the antitubercular chemotherapeutic arsenal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23301038
DOI: 10.1371/journal.pone.0053162
PMCID: PMC3536773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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