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Modeling the Structural Origins of Drug Resistance to Isoniazid via key Mutations in <i>Mycobacterium tuberculosis</i> Catalase-Peroxidase, KatG

2017-12-07

Abstract excerpt

WHO reported 10.4 million new tuberculosis (TB) cases and 1.8 million deaths in 2015, making M. tuberculosis the most successful human pathogen with highest mortality among infectious diseases.[1,2] Drug-resistant TB is a major threat to global TB control.[2,3] Recently Torres et al. [4] identified 14 novel substitutions in M. tuberculosis-KatG (the enzyme associated with resistance to isoniazid—an important fir...

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Literature Corpus work
0d26a63a-7843-5b2a-b71b-4ea96345f674
DOI
10.1101/230482
Open publication

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Modeling the Structural Origins of Drug Resistance to Isoniazid via key Mutations in <i>Mycobacterium tuberculosis</i> Catalase-Peroxidase, KatGDOI 10.1101/230482
Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG.Semantic proximity
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